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14-3-3 PROTEINS
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DeCS
Descriptor
English
:
14-3-3 Proteins
Descriptor
Spanish
:
Proteínas 14-3-3
Descriptor
Portuguese
:
Proteínas 14-3-3
Tree Number:
D12.644.360.024.050
D12.776.157.057.002
D12.776.476.024.050
Definition
English
:
A large
family
of signal-transducing adaptor
proteins
present in wide variety of
eukaryotes
. They are
PHOSPHOSERINE
and
PHOSPHOTHREONINE
binding
proteins
involved in important cellular processes including
SIGNAL TRANSDUCTION
;
CELL CYCLE
control
;
APOPTOSIS
; and cellular stress responses.
14-3-3 proteins
function by interacting with other signal-transducing
proteins
and effecting changes in their enzymatic activity and subcellular localization. The name 14-3-3 derives from numerical designations used in the original fractionation patterns of the
proteins.
History Note
English
:
2005(1981)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
38740
Unique Identifier:
D048948
Occurrence in VHL
:
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